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Reducing l-lactate release from hippocampal astrocytes by intracellular oxidation increases novelty induced activity in mice.

Vaccari Cardoso B, Shevelkin AV, Terrillion C, Mychko O, Mosienko V, Kasparov S, Pletnikov MV, Teschemacher AG
Glia. 2021 Jan 5. doi: 10.1002/glia.23960. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
166877pCMV-LOx-IRES-EGFPExpress the bacterial lactate oxidase (LOx) enzyme in mammalian cells
166919pTYF-sGFAP-LOx-IRES-tdTomatoExpress the bacterial lactate oxidase (LOx) enzyme in astrocytes
166920pTYF-sGFAP-IRES-tdTomatoEmpty plasmid backbone; includes IRES-tdTomato and sGFAP promoter

Antibodies from Article