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Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.

Verardi R, Lindesmith LC, Tsybovsky Y, Gorman J, Chuang GY, Edwards CE, Brewer-Jensen PD, Mallory ML, Ou L, Schon A, Shi W, Tully ES, Georgiou G, Baric RS, Kwong PD
NPJ Vaccines. 2020 Dec 14;5(1):110. doi: 10.1038/s41541-020-00260-w. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
162580pFastBac1_GI.1_N116C-G193CExpresses norovirus GI.1 VP1 protein with mutations N116C-G193C in Sf9 insect cells
162581pFastBac1_GI.1_Q62C-A140CExpresses norovirus GI.1 VP1 protein with mutations Q62C-A140C in Sf9 insect cells
162582pFastBac1_GI.1_A37C-A44CExpresses norovirus GI.1 VP1 protein with mutations A37C-A44C in Sf9 insect cells
162583pFastBac1_GI.1_A37I-A44LExpresses norovirus GI.1 VP1 protein with mutations A37I-A44L in Sf9 insect cells
162584pFastBac1_GI.1_Q141V-P221LExpresses norovirus GI.1 VP1 protein with mutations Q141V-P221L in Sf9 insect cells
162585pFastBac1_GI.1_L144C-P221CExpresses norovirus GI.1 VP1 protein with mutations L144C-P221C in Sf9 insect cells
162586pFastBac1_GI.1_G131C-N172CExpresses norovirus GI.1 VP1 protein with mutations G131C-N172C in Sf9 insect cells
162587pFastBac1_GI.1_N167C-L169CExpresses norovirus GI.1 VP1 protein with mutations N167C-L169C in Sf9 insect cells

Antibodies from Article