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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase epsilon.

Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R
Mol Cell. 2020 Oct 28. pii: S1097-2765(20)30723-1. doi: 10.1016/j.molcel.2020.10.016. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
160762pLKO.1P POLE1_1Suppress POLE1
160763pLKO.1B POLE1_1Suppress POLE1
160764pLKO.1P POLE1_2Suppress POLE1
160765pLKO.1B POLE1_2Suppress POLE1
160766pLKO.1P POLE2Suppress POLE2
160767pLKO.1B CDC25A_1Suppress CDC25A
160768pLKO.1B CDC25A_2Suppress CDC25A
160769pLKO.1B CDC25C_1Suppress CDC25C
160770pLKO.1B CDC25C_2Suppress CDC25C
160771pLKO.1P BRIP1_1Suppress BRIP1
160772pLKO.1P BRIP1_2Suppress BRIP1
160773pLKO.1P CISD1_1Suppress CISD1
160774pLKO.1P CISD1_2Suppress CISD1
160775pLKO.1P CISD2_1Suppress CISD2
160776pLKO.1P CISD2_2Suppress CISD2
160777pLKO.1P DDX11_1Suppress DDX11
160778pLKO.1P DDX11_2Suppress DDX11
160779pLKO.1P DNA2_1Suppress DNA2
160780pLKO.1P DNA2_2Suppress DNA2
160781pLKO.1P ERCC2_1Suppress ERCC2
160782pLKO.1P ERCC2_2Suppress ERCC2
160783pLKO.1P EXO5_1Suppress EXO5
160784pLKO.1P EXO5_2Suppress EXO5
160785pLKO.1P MUTYH_1Suppress MUTYH
160786pLKO.1P MUTYH_2Suppress MUTYH
160787pLKO.1P NTHL1_1Suppress NTHL1
160788pLKO.1P NTHL1_2Suppress NTHL1
160789pLKO.1P POLA1_1Suppress POLA1
160790pLKO.1P POLA1_2Suppress POLA1
160791pLKO.1P POLD1_1Suppress POLD1
160792pLKO.1P POLD1_2Suppress POLD1
160793pLKO.1P PPAT_1Suppress PPAT
160794pLKO.1P PPAT_2Suppress PPAT
160795pLKO.1P PRIM2_1Suppress PRIM2
160796pLKO.1P PRIM2_2Suppress PRIM2
160797pLKO.1P REV3L_1Suppress REV3L
160798pLKO.1P REV3L_2Suppress REV3L
160799pLKO.1P RTEL1_1Suppress RTEL1
160800pLKO.1P RTEL1_2Suppress RTEL1
160801pCW57.1 DOX off blast NFS1Express Dox repressible NFS1
160802pMXS-IRES-Blast POLE1Express POLE1
160803pMXS-IRES-Blast POLE1 N-ISCmutExpress N-terminal ISC mutant POLE1
160804pMXS-IRES-Blast POLE1 C-ISCmutExpress C-terminal ISC mutant POLE1
160805pMXS-IRES-Blast POLD1Express POLD1
160806pMXS-IRES-Blast POLD1 ISCmutExpress ISC mutant POLD1
160807pMXS-IRES-Blast POLA1Express POLA1
160808pMXS-IRES-Blast POLA1 ISCmutExpress ISC mutant POLA1
160809pMXS-IRES-Blast HA-POLE2Express HA-tagged POLE2
160810Tet-pLKO-puro shPOLE1_1Express Dox repressible shPOLE1

Antibodies from Article