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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S
Sci Transl Med. 2021 Mar 3;13(583). pii: 13/583/eaaz4564. doi: 10.1126/scitranslmed.aaz4564. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
160541pGS_101Expresses Human APOE4 with a yeast secretory signal peptide under the control of the yeast Gal promoter
160650pGS_107Expresses Human APOE4 with a yeast secretory signal peptide under the control of the yeast Gal promoter
160651pGS_128Expresses Human APOE3 with a yeast secretory signal peptide under the control of a beta-estradiol inducible promoter
160652pGS_129Expresses Human APOE4 with a yeast secretory signal peptide under the control of a beta-estradiol inducible promoter
160653pGS_591Expresses OLE1 under the control of the yeast Sup35 promoter

Antibodies from Article