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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.

Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28046-28055. doi: 10.1073/pnas.2016093117. Epub 2020 Oct 22. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
159757pCVD013Expression vector for wild-type Fc-fused ACE2(614)
159762pCVD208Expression vector for wild-type Fc-fused ACE2(740)
159765pCVD293Expression vector for mutated Fc-fused ACE2(740)
159771pCVD313Expression vector for mutated Fc-fused ACE2(740)

Antibodies from Article