KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
Au YZ, Gu M, De Braekeleer E, Gozdecka M, Aspris D, Tarumoto Y, Cooper J, Yu J, Ong SH, Chen X, Tzelepis K, Huntly BJP, Vassiliou G, Yusa K
Leukemia. 2021 Apr;35(4):1012-1022. doi: 10.1038/s41375-020-1001-z. Epub 2020 Aug 6.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 159287 | pKLV2-U6gRNA5(gKAT7-5)-PGKpuro2ABFP-W | Lentiviral vector expressing gRNA targeting KAT7 (gRNA ID. 5) |
| 159288 | pKLV2-U6gRNA5(gKAT7-A10)-PGKpuro2ABFP-W | Lentiviral vector expressing gRNA targeting KAT7 (gRNA ID. A10) |
| 159289 | pKLV2-U6gRNA5(gKAT6A-A7)-PGKpuro2ABFP-W | Lentiviral vector expressing gRNA targeting KAT6A (gRNA ID. A7) |
| 159290 | pKLV2-U6gRNA5(gKAT6A-A8)-PGKpuro2ABFP-W | Lentiviral vector expressing gRNA targeting KAT6A (gRNA ID. A8) |
| 159291 | pKLV-EF1aGFP-W | Lentiviral vector expressing GFP driven by human EF1a promoter |
| 159292 | pKLV-EF1aGFP2AKAT7-W | Lentiviral vector expressing GFP and KAT7 (gRNA-resistant) driven by human EF1a promoter |
| 159293 | pKLV-EF1aGFP2AKAT7(E508Q)-W | Lentiviral vector expressing GFP and KAT7 (gRNA-resistant, E508Q mutant) driven by human EF1a promoter |
| 159294 | pKLV-EF1aGFP2AKAT7-linker-mAID-W | Lentiviral vector expressing GFP and KAT7 (gRNA-resistant, mAID-tagged) driven by human EF1a promoter |
| 159295 | pKLV-EF1amCherry-W | Lentiviral vector expressing mCherry driven by human EF1a promoter |
| 159296 | pKLV-EF1amCherry-2A-OsTIR1-W | Lentiviral vector expressing mCherry and OsTIR1 driven by human EF1a promoter for the auxin-inducible degron (AID) system |