mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR.
Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M
Mol Cell. 2011 Oct 21;44(2):317-24. doi: 10.1016/j.molcel.2011.09.005.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 159159 | pcDNA3-HA-DEPTOR-WT | Expresses DEPTOR in mammalian cells |
| 159160 | pcDNA3-HA-DEPTOR S286/287/291A | Expresses DEPTOR S286/287/291A mutant in mammalian cells |
| 159161 | pcDNA3-HA-DEPTOR S286/287/291D | Expresses DEPTOR S286/287/291D mutant in mammalian cells |