Clustering of the zeta-Chain Can Initiate T Cell Receptor Signaling.

Ma Y, Lim YJ, Benda A, Lou J, Goyette J, Gaus K
Int J Mol Sci. 2020 May 15;21(10). pii: ijms21103498. doi: 10.3390/ijms21103498. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
153546	LIC-Z-Y-L	this is signaling incompetent version of LIC-Z where all Tyrosine residues in ITAMs are mutated to leucine
153545	LIC-Z-delCry2	this is the non-clustering version of LIC-Z tagged with mcherry
153544	LIC-Z-YFP	perform light induced optogenetic clustering of TCR ζ-Chain tagged with yellow fluorescent protein as described in the associated publication
153543	LIC-Z	perform light induced optogenetic clustering of TCR ζ-Chain as described in the associated publication