Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). pii: 2107208118. doi: 10.1073/pnas.2107208118.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 153419 | MBC1-PuroIII | MSCV backbone with murine TCR-alpha signal peptide and murine TCR-beta1 constant region (TRBC1) for expression of TCR genes |
| 153420 | MBC2-PuroIII | MSCV backbone with murine TCR-alpha signal peptide and murine TCR-beta2 constant region (TRBC2) for expression of TCR genes |
| 153421 | CaP2AIII_pK18 | Source of murine TCR-alpha constant region (TRAC*02) gene followed by P2A |
| 162748 | MBC1-null | MSCV backbone with murine TCR-alpha signal peptide and murine TCR-beta1 constant region (TRBC1) for expression of TCR genes |
| 162749 | MBC2-null | MSCV backbone with murine TCR-alpha signal peptide and murine TCR-beta2 constant region (TRBC2) for expression of TCR genes |