The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner.
Ogawa J, Zhu W, Tonnu N, Singer O, Hunter T, Ryan AL, Pao GM
bioRxiv. 2020 Jul 22. doi: 10.1101/2020.07.21.214932.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 141347 | pBOB-CAG-SARS-CoV2-Spike-HA | 3. Generation lentiviral vector expressing the codon optimized SARS-CoV2 Spike Glycoprotein ORF with a C-terminal HA tag generated by Junko Ogawa & Gerald M Pao |
| 158761 | pBOB-CAG-SARS-CoV2-Spike D614G-HA | 3rd Generation lentiviral vector expressing the codon optimized SARS-CoV2 Spike Glycoprotein D614G high infectivity mutant with a C-terminal HA tag generated by Junko Ogawa & Gerald M Pao |