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CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

Chen SH, Jang GM, Huttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ
EMBO J. 2018 Sep 14;37(18). pii: embj.201797508. doi: 10.15252/embj.201797508. Epub 2018 Aug 30. (Link opens in a new window) PubMed (Link opens in a new window) Article

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