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PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.

Yadav L, Pietila E, Ohman T, Liu X, Mahato AK, Sidorova Y, Lehti K, Saarma M, Varjosalo M
iScience. 2020 Feb 21;23(2):100871. doi: 10.1016/j.isci.2020.100871. Epub 2020 Jan 31. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
139611PTPRA-SHCStrepIII-HA-tagged gene expression
139612PTPRA_C433S-SHCStrepIII-HA-tagged gene expression
139614PTPRA_Y789F-SHCStrepIII-HA-tagged gene expression
139615PTPRA_deltaD1-SHCStrepIII-HA-tagged gene expression
139617RET-SHCStrepIII-HA-tagged gene expression
139618MEN2A-SHCStrepIII-HA-tagged gene expression
139619MEN2B-SHCStrepIII-HA-tagged gene expression
139620RET_Y1062F-SHCStrepIII-HA-tagged gene expression
139621RET_Y981F-SHCStrepIII-HA-tagged gene expression
139623GRB2-SHCStrepIII-HA-tagged gene expression
139624GDNF-SHCStrepIII-HA-tagged gene expression
139625GRB2-SHNStrepIII-HA-tagged gene expression
139627RET-V5V5-His-tagged gene expression
139628RET_KD-V5V5-His-tagged gene expression
139629MEN2A-V5V5-His-tagged gene expression
139630MEN2B-V5V5-His-tagged gene expression
139631GRB2-V5V5-His-tagged gene expression
139632PTPRA-MACMAC-tagged gene expression
139634MEN2A-MACMAC-tagged gene expression
139638PTPRA_C433S-GFP fusionGFP-tagged gene expression
139639PTPRA_C723S-GFP fusionGFP-tagged gene expression
139640PTPRA_deltaD1-GFP fusionGFP-tagged gene expression
139641PTPRA_deltaD2-GFP fusionGFP-tagged gene expression
139644phR-LucMammalian gene expression

Antibodies from Article