Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.
Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Ronnblom L, Michel F, Pellegrini S
J Immunol. 2013 Mar 1;190(5):2335-44. doi: 10.4049/jimmunol.1203118. Epub 2013 Jan 28.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 139350 | pRC/CMV-TYK2P1104A-VSV | Expression of the TYK2-P1104A variant, rs34536443 |
| 139351 | pRC/CMV-TYK2VF/PA-VSV | Expression of the double mutant of TYK2-V678F-P1104A |
| 139357 | pRC/CMV-JAK1K908E-VSV | Expression of kinase-dead JAK1-K908E protein |
| 139358 | pRC/CMV-JAK1P1084A-VSV | Expression of the catalytically impaired JAK1-P1084A mutant (corresponding to TYK2-P1104A) |