The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.
Gakovic M, Ragimbeau J, Francois V, Constantinescu SN, Pellegrini S
J Biol Chem. 2008 Jul 4;283(27):18522-9. doi: 10.1074/jbc.M801427200. Epub 2008 May 2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 139349 | pRC/CMV-TYK2V678F-VSV | Expression of a gain of function TYK2-V678F protein (correspoding to JAK2-V617F) |