Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.

Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S
J Biol Chem. 1996 Aug 23;271(34):20494-500. doi: 10.1074/jbc.271.34.20494. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
139348	pRC/CMV-TYK2K930R-FF-VSV	Expression of kinase-dead TYK2-K930R missing the two tyrosines at the activation loop
139347	pRC/CMV-TYK21054-5FF-VSV	Expression of TYK2 protein mutated in the two tyrosines (Y1054F/Y1055F) of the activation loop
139346	pRC/CMV-TYK2K930R-VSV	Expression of kinase-dead TYK2-K930R protein
139345	pRC/CMV-TYK2V362F-VSV	Expression of TYK2 V362F protein (rs2304256)