Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.
Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S
J Biol Chem. 1996 Aug 23;271(34):20494-500. doi: 10.1074/jbc.271.34.20494.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 139345 | pRC/CMV-TYK2V362F-VSV | Expression of TYK2 V362F protein (rs2304256) |
| 139346 | pRC/CMV-TYK2K930R-VSV | Expression of kinase-dead TYK2-K930R protein |
| 139347 | pRC/CMV-TYK21054-5FF-VSV | Expression of TYK2 protein mutated in the two tyrosines (Y1054F/Y1055F) of the activation loop |
| 139348 | pRC/CMV-TYK2K930R-FF-VSV | Expression of kinase-dead TYK2-K930R missing the two tyrosines at the activation loop |