Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells.

Earle AJ, Kirby TJ, Fedorchak GR, Isermann P, Patel J, Iruvanti S, Moore SA, Bonne G, Wallrath LL, Lammerding J
Nat Mater. 2019 Dec 16. pii: 10.1038/s41563-019-0563-5. doi: 10.1038/s41563-019-0563-5. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID	Plasmid	Purpose
132773	pCDH-CMV-hLamin_A-IRES-copGFP-EF1-puro	Expression of human LMNA.
187017	GFP-KASH2	Inducible disruption of LINC Complex
187018	GFP-KASH2ext	Control for inducible disruption of LINC Complex