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Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.

Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R
Science. 2019 Nov 1;366(6465):589-593. doi: 10.1126/science.aay0934. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
138296pMtb MCMExpression of Mtb MCM small and large subunit
138297pMtb ATRExpression of Mtb ATR
138298pMtb CblAExpression of Mtb CblA

Antibodies from Article