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Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.

Wang Z, Michaud GA, Cheng Z, Zhang Y, Hinds TR, Fan E, Cong F, Xu W
Genes Dev. 2012 Feb 1;26(3):235-40. doi: 10.1101/gad.182618.111. Epub 2012 Jan 19. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
132613pGEX4T-1 human RNF146 WWE (99-183)expresses human RNF146 WWE (99-183) in E. coli
132614pGEX6P-1 human HUWE1 WWE (1611-1703)expresses human HUWE1 WWE (1611-1703) in E. coli

Antibodies from Article