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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes.

Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W
Hepatology. 2019 Jun 12. doi: 10.1002/hep.30807. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
138182TRRAP sgRNA13rd generation lentiviral gRNA plasmid targeting human TRRAP
138183TRRAP sgRNA23rd generation lentiviral gRNA plasmid targeting human TRRAP
138184TRRAP sgRNA33rd generation lentiviral gRNA plasmid targeting human TRRAP
138185KAT2A sgRNA13rd generation lentiviral gRNA plasmid targeting human KAT2A
138186KAT2A sgRNA23rd generation lentiviral gRNA plasmid targeting human KAT2A
138187KAT5 sgRNA13rd generation lentiviral gRNA plasmid targeting human KAT5
138188KAT5 sgRNA23rd generation lentiviral gRNA plasmid targeting human KAT5
138189CDKN1A sgRNA3rd generation lentiviral gRNA plasmid targeting human CDKN1A
138190TOP2A sgRNA13rd generation lentiviral gRNA plasmid targeting human TOP2A
138191TOP2A sgRNA23rd generation lentiviral gRNA plasmid targeting human TOP2A
138273pBV-luc TOP2A 500bp promoterLuciferase reporter plasmid driven by TOP2A promoter
138274pBV-luc TOP2A 1kb promoterLuciferase reporter plasmid driven by TOP2A promoter

Antibodies from Article