Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown KM, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI
Science. 2023 Apr 21;380(6642):eabn7625. doi: 10.1126/science.abn7625. Epub 2023 Apr 21.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 127338 | Cdk13_intron3_sg3_pX458 | sgRNA that cuts within intron 3 of mouse CDK13 genomic locus- guide #3 |
| 127339 | Cdk13_intron3_sg4_pX458 | sgRNA that cuts within intron 3 of mouse CDK13 genomic locus- guide #4 |
| 127340 | Cdk13_intron4_sg3_pX330 | sgRNA that cuts within intron 4 of mouse CDK13 genomic locus- guide #3 |
| 127341 | Cdk13_intron4_sg4_pX330 | sgRNA that cuts within intron 4 of mouse CDK13 genomic locus- guide #4 |
| 127342 | pCR8/GW_TOPO_Cdk13_Untagged | Untagged mouse Cdk13 transgene (NP_001074527.1 isoform) cloned into Gateway entry vector |
| 127343 | pCR8/GW_TOPO_Cdk13_Nterm_FlagHa | N-terminal Flag- HA- tandem epitope tagged mouse Cdk13 transgene (NP_001074527.1 isoform) cloned into Gateway entry vector |
| 127344 | PB-Neo-TetO-Cdk13_Untagged | Untagged mouse Cdk13 transgene (NP_001074527.1 isoform) cloned into a dox-inducible piggybac destination vector |
| 127345 | PB-Neo-TetO-Cdk13_Nterm_FlagHa | N-terminal Flag- HA- tandem epitope tagged mouse Cdk13 transgene (NP_001074527.1 isoform) cloned into a dox-inducible piggybac destination vector |