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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.

Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T
Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
127161pRSFDuet-sumo-h-cGASexpression of human cGAS protein
127162pRSFDuet-sumo-h-cGASCD(K427E/K428E)expression of truncated human cGAS protein

Antibodies from Article