CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Dubbury SJ, Boutz PL, Sharp PA
Nature. 2018 Dec;564(7734):141-145. doi: 10.1038/s41586-018-0758-y. Epub 2018 Nov 28.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 127174 | Cdk12_intron3_sg2_pX330 | sgRNA that cuts within intron 3 of mouse Cdk12 genomic locus in pX330 backbone |
| 127175 | Cdk12_intron4_sg1_pX458 | sgRNA that cuts within intron 4 of mouse CDK12 genomic locus in pX458 backbone |
| 127176 | pCR8/GW_TOPO_Cdk12_Untagged | Untagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into Gateway entry vector |
| 127177 | pCR8/GW_TOPO_Cdk12_Nterm_FlagHa | N-terminal Flag- HA- tandem epitope tagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into Gateway entry vector |
| 127178 | PB-Neo-TetO-Cdk12_Untagged | Untagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into a dox-inducible piggybac destination vector |
| 127179 | PB-Neo-TetO-Cdk12_Nterm_FlagHa | N-terminal Flag- HA- tandem epitope tagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into a dox-inducible piggybac destination vector |