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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.

Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, Inghirami G, Coleman CN, Formenti SC, Demaria S
Nat Commun. 2017 Jun 9;8:15618. doi: 10.1038/ncomms15618. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
127696pTRIPZ shNSDoxycyclin inducible pTRIPZ lentivirus vector containing a non-silencing sequence for both human and mouse
127697pTRIPZ shSTING-MmuDoxycyclin inducible shRNA knockdown of mouse STING gene
127698pTRIPZ shcGAS-MmuDoxycyclin inducible shRNA knockdown of mouse cGAS gene
127699pTRIPZ shIFNARDoxycyclin inducible shRNA knockdown of mouse IFNAR gene
127700pTRIPZ shTREX1Doxycyclin inducible shRNA knockdown of both human and mouse TREX1 gene
127701pTRIPZ TREX1-KIFor knocking in TREX1 in mouse - Doxycyclin inducible
128158pTRIPZ shSTING-HsaDoxycyclin inducible shRNA knockdown of human STING gene
128175pTRIPZ shcGAS-HsaDoxycyclin inducible shRNA knockdown of human cGAS gene

Antibodies from Article