Direct activation of Epac by sulfonylurea is isoform selective.
Herbst KJ, Coltharp C, Amzel LM, Zhang J
Chem Biol. 2011 Feb 25;18(2):243-51. doi: 10.1016/j.chembiol.2010.12.007.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 138196 | pcDNA3.1-Cerulean-Epac2-Venus | FRET-based biosensor for monitoring Epac2 activation. |
| 138197 | pcDNA3.1-Cerulean-Epac2(R53A)-Venus | FRET-based Epac2 activation sensor with R53A mutation in Epac2 coding sequence. |
| 138198 | pcDNA3.1-Cerulean-Epac2(R447)-cpV[E172] | FRET-based Epac2 activation sensor with R447A mutation in Epac2 coding sequence. |
| 138199 | pcDNA3.1-Cerulean-Epac2(R466A)-Venus | FRET-based Epac2 activation sensor with R466A mutation in Epac2 coding sequence. |
| 138200 | pcDNA3.1-Cerulean-Epac2(L426W)-Venus | FRET-based Epac2 activation sensor with L426W mutation in Epac2 coding sequence. |