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Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.

Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi YY, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A
JCI Insight. 2019 Aug 8;4(15). pii: 127098. doi: 10.1172/jci.insight.127098. eCollection 2019 Aug 8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
122230plx304-PHB-V5Expresses human PHB attached to a V5 tag
122231pLKO-PHB-4Expresses shRNA targeting the 3' UTR of human PHB
122232pLKO-PHB-6Expresses shRNA targeting the coding sequence of human PHB
122233pLKO-PHB-8Expresses shRNA targeting the coding sequence of human PHB

Antibodies from Article