Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.
Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR
Nat Biotechnol. 2019 May 20. pii: 10.1038/s41587-019-0134-y. doi: 10.1038/s41587-019-0134-y. PubMed Article
Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR
Nat Biotechnol. 2019 May 20. pii: 10.1038/s41587-019-0134-y. doi: 10.1038/s41587-019-0134-y. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 119801 | CP1012-CBEmax | C-to-T base editor |
| 119802 | CP1028-CBEmax | C-to-T base editor |
| 119803 | CP1041-CBEmax | C-to-T base editor |
| 119804 | CP1249-CBEmax | C-to-T base editor |
| 119805 | CP1300-CBEmax | C-to-T base editor |
| 119806 | CP1012-ABEmax | A-to-G base editor |
| 119807 | CP1028-ABEmax | A-to-G base editor |
| 119808 | CP1041-ABEmax | A-to-G base editor |
| 119809 | CP1249-ABEmax | A-to-G base editor |
| 119810 | CP1300-ABEmax | A-to-G base editor |
| 119811 | VRQR-ABEmax | A-to-G base editor |
| 119812 | VRER-ABEmax | A-to-G base editor |
| 119813 | xABEmax | A-to-G base editor |
| 119814 | SaABEmax | A-to-G base editor |
| 119815 | SaKKH-ABEmax | A-to-G base editor |
| 124163 | NG-ABEmax | A-to-G base editor |