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The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling.

van Unen J, Botman D, Yin T, Wu YI, Hink MA, Gadella TWJ Jr, Postma M, Goedhart J
BMC Cell Biol. 2018 Jun 7;19(1):6. doi: 10.1186/s12860-018-0155-2. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
84334mCherry-C1-TGATExpresses TGAT tagged with mCherry
84336mCherry-C1-TGAT(C242S,C253S)Expresses TGAT tagged with mCherry
84337pLck-mVenus-C1Expresses a mVenus tagged with a membrane localization sequence

Antibodies from Article