CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N
Science. 2018 Dec 13. pii: science.aau0629. doi: 10.1126/science.aau0629.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 115790 | pCMV-sadCas9-VP64 | An AAV vector expressing S. aureus dCas9 fused to VP64. |
| 115794 | pCMV-SpdCas9-VP64 | Expresses SpdCas9-Vp64 fusion protein when packaged into AAV |