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Expanded CAG/CTG repeats resist gene silencing mediated by targeted Epigenome editing.

Yang B, Borgeaud AC, Buricova M, Aeschbach L, Rodriguez-Lima O, Ruiz Buendia GA, Cinesi C, Taylor AS, Baubec T, Dion V
Hum Mol Genet. 2021 Sep 7. pii: 6365982. doi: 10.1093/hmg/ddab255. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
114393pAB-NEO-PYLFor PYL expression
114394pAB(EXPR-PYL-HDAC3-NEO)For PYL-HDAC3 expression
114395pAB(EXPR-PYL-HDAC5-NEO)For PYL-HDAC5 expression
114396pAB(EXPR-PYL-DNMT1-NEO)For PYL-DNMT1 expression
114397pAB-HDAC5(mut-H-A)For PYL-HDAC5 H1006A expression
114398pAB-HDAC5(mut-H-Y)For PYL-HDAC5 H1006Y expression
114399pAB(EXPR-DS-HDAC5_HDAC3)For PYL-HDAC5 catalytic domain swap to HDAC3 catalytic domain expression
114400pAB(EXPR-HDAC5-trun1)For PYL-HDAC5 aa 1-275 expression
114401pAB-EXPR(PYL-cat_dom_HDAC5)For PYL-HDAC5 catalytic domain expression
114402pAB-EXPR(PYL-Nterm_dom_HDAC5)For PYL-HDAC5 N terminal domain expression

Antibodies from Article