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Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.

Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr, Harvey CJ, Kobold S, Pyrdol JW, Yoon C, Yuan GC, Hodi FS, Dranoff G, Wucherpfennig KW
Science. 2018 Mar 30;359(6383):1537-1542. doi: 10.1126/science.aao0505. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
114007pHAGE-EF1a MICA*009-IRES-ZsGreenInduces expression of human MICA allele 009 cDNA
114008pHAGE-EF1a-MICB*005-IRES-ZsGreenInduces expression of human MICB allele 005 cDNA

Antibodies from Article