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Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.

Tang MY, Vranas M, Krahn AI, Pundlik S, Trempe JF, Fon EA
Nat Commun. 2017 Mar 9;8:14697. doi: 10.1038/ncomms14697. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
115616eGFP-pk-F146AExpresses human Parkin F146A in mammalian cells
115617eGFP-pk-N273KExpresses human Parkin N273K in mammalian cells
115618eGFP-pk-H302AExpresses human Parkin H302A in mammalian cells
115619eGFP-pk-S65AExpresses human Parkin S65A in mammalian cells

Antibodies from Article