Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.
Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG
J Biol Chem. 1994 Oct 14;269(41):25699-709.
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PubMed
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 107973 | pcDNA3-MKK1 | expression of MAP Kinase Kinase |
| 107974 | pcDNA3-MKK1K97A | expression of a dominant negative MAP Kinase Kinase |