cGAS surveillance of micronuclei links genome instability to innate immunity.
Mackenzie KJ, Carroll P, Martin CA, Murina O, Fluteau A, Simpson DJ, Olova N, Sutcliffe H, Rainger JK, Leitch A, Osborn RT, Wheeler AP, Nowotny M, Gilbert N, Chandra T, Reijns MAM, Jackson AP
Nature. 2017 Aug 24;548(7668):461-465. doi: 10.1038/nature23449. Epub 2017 Jul 24.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 108674 | pMSCVpuro-eGFP-hcGAS | For production of retrovirus and transduction of mammalian cells, allowing expression of N-terminally eGFP-tagged human cGAS |
| 108675 | pMSCVpuro-eGFP-mcGAS | For production of retrovirus and transduction of mammalian cells, allowing expression of N-terminally eGFP-tagged mouse cGAS |
| 108676 | pGEX6P1-hcGAS(157-522) | For expression in E.coli and affinity purification of N-terminally GST-tagged human cGAS amino acid 157-522 |