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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.

Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR
Nature. 2018 Feb 28. pii: nature26155. doi: 10.1038/nature26155. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
108379xCas9 3.7Mammalian expression vector for xCas9 3.7
108380xCas9(3.7)-BE3Mammalian expression vector for xCas9(3.7)-BE3
108381xCas9(3.7)-BE4Mammalian expression vector for xCas9(3.7)-BE4
108382xCas9(3.7)-ABE(7.10)Mammalian expression vector for xCas9(3.7)-ABE
108383dxCas(3.7)-VPRMammalian expression vector for xCas9 3.7 with VP64-p65-Rta (VPR) fused to its C-terminus
108384xCas9 3.6Mammalian expression vector for xCas9 3.6
108385xCas9(3.6)-BE3Mammalian expression vector for xCas9(3.6)-BE3
108386xCas9(3.6)-BE4Mammalian expression vector for xCas9(3.6)-BE4
108387xCas9(3.6)-ABE(7.10)Mammalian expression vector for xCas9(3.6)-ABE
108388dxCas(3.6)-VPRMammalian expression vector for xCas9 3.6 with VP64-p65-Rta (VPR) fused to its C-terminus

Antibodies from Article