Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.
Gao W, Li W, Xiao T, Liu XS, Kaelin WG Jr
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1027-1032. doi: 10.1073/pnas.1619726114. Epub 2017 Jan 12.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 107399 | shPBRM1#32-Tet-pLKO-puro | Lentiviral expression of shRNA targeting PBRM |
| 107400 | shPBRM1#131-Tet-pLKO-puro | Lentiviral expression of shRNA targeting PBRM |
| 107401 | shPBRM1 #122-Tet-pLKO-puro | Lentiviral expression of shRNA targeting PBRM |
| 107402 | sgCtr- LentiCRISPRv2 | Lentiviral expression of Cas9 and a control gRNA |
| 107403 | sgPBRM1-1- LentiCRISPRv2 | Lentiviral expression of Cas9 and gRNA targeting PBRM1 |
| 107404 | sgPBRM1-2- LentiCRISPRv2 | Lentiviral expression of Cas9 and gRNA targeting PBRM1 |
| 107407 | pLenti-PGK-Hygro-amp-sgRNA-resistant PBRM1 | Lentiviral expression of gRNA resistant PBRM1 |