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IFITM3 requires an amphipathic helix for antiviral activity.

Chesarino NM, Compton AA, McMichael TM, Kenney AD, Zhang L, Soewarna V, Davis M, Schwartz O, Yount JS
EMBO Rep. 2017 Oct;18(10):1740-1751. doi: 10.15252/embr.201744100. Epub 2017 Aug 23. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
104361myc-hIFITM3-delta59-68Expresses human IFITM3-delta59-68 with an N-terminal myc tag in mammalian cells.
104362myc-hIFITM3-S61A,N64A,T65AExpresses human IFITM3-S61A,N64A,T65A with an N-terminal myc tag in mammalian cells.
104363myc-hIFITM3-F63QExpresses human IFITM3-F63Q with an N-terminal myc tag in mammalian cells.

Antibodies from Article