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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Jing H, Hu J, He B, Negron Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H
Cancer Cell. 2016 Mar 14;29(3):297-310. doi: 10.1016/j.ccell.2016.02.007. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
102622pET28a-6XHis-SUMO-SIRT2Expresses a truncation (aa38-356) of human SIRT2 isoform 1 in bacteria for purification
102623pCMV4a-SIRT2-FlagExpresses full length SIRT2 isoform 1 in mammalian cells
102624pCDH-SIRT2-FlagExpresses full length SIRT2 isoform 1 in mammalian cells
102625pCMV4a-Flag-c-MycExpresses c-Myc in mammalian cells
102626pCDH-Flag-c-MycExpresses c-Myc in mammalian cells

Antibodies from Article