Histidine catabolism is a major determinant of methotrexate sensitivity.
Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM
Nature. 2018 Jul 11. pii: 10.1038/s41586-018-0316-7. doi: 10.1038/s41586-018-0316-7.
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Plasmids from Article
ID | Plasmid | Purpose |
---|---|---|
102312 | pLentiCRISPR sgFTCD_1 | genetic depletion of FTCD |
102313 | pLentiCRISPR sgFTCD_2 | genetic depletion of FTCD |
102314 | pLentiCRISPR sgSLC19A1 | genetic depletion of SLC19A1 |
102315 | pLentiCRISPR sgHAL | genetic depletion of HAL |
102316 | pLentiCRISPR sgAMDHD1 | genetic depletion of AMDHD1 |
102317 | pWP1_mFTCD | expression of mouse cDNA of FTCD, refractory to the guides in plasmids 1,2 |
102318 | pWP1_mHAL | expression of mouse cDNA of HAL refractory to the guide in plasmid 4 |
102320 | FUW-RLuc-T2A-PuroR | expression of r-luciferase |