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Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sanchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V
Nat Neurosci. 2017 Aug;20(8):1172-1179. doi: 10.1038/nn.4593. Epub 2017 Jun 26. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
99113pAAV-TRE-mTurquoise2An AAV genome with tet-inducible expression of the fluorescent protein mTurquoise2
99114pAAV-TRE-mRuby2An AAV genome with tet-inducible expression of the fluorescent protein mRuby2
99115pAAV-TRE-DIO-mTurquoise2An AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mTurquoise2
99116pAAV-TRE-DIO-tdTomatoAn AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein tdTomato
99117pAAV-TRE-DIO-mRuby2An AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mRuby2
99118pAAV-CAG-tTAAn AAV genome that ubiquitously expresses tTA from the CAG promoter
99119pAAV-hSyn1-tTAAn AAV genome that expresses tTA from the hSyn1 promoter
99120pAAV-ihSyn1-tTAAn AAV genome that expresses tTA from the hSyn1 promoter that contains a positive feedback loop for amplifed expression of the tTA
99121pAAV-ihSyn1-DIO-tTAAn AAV genome with Cre-dependent expression of the tTA from the hSyn1 promoter. Contains a positive feedback loop for amplifed expression of the tTA
99122pAAV-CAG-mTurquoise2An AAV genome that ubiquitously expresses the fluorescent protein mTurquoise2 from the CAG promoter
99123pAAV-CAG-mRuby2An AAV genome that ubiquitously expresses the fluorescent protein mRuby2 from the CAG promoter
99125pAAV-hSyn1-mTurquoise2An AAV genome that expresses the fluorescent protein mTurquoise2 from the hSyn1 promoter
99126pAAV-hSyn1-mRuby2An AAV genome that expresses the fluorescent protein mRuby2 from the hSyn1 promoter
99128pAAV-mTH-GFPAn AAV genome that expresses GFP from the mouse TH promoter
99129pAAV-GFAP-mKate2.5fAlso known as pAAV-GFAP-mKate2.5-f. An AAV genome that express the farnesylated fluorescent protein mKate2.5 from the GFAP promoter
99130pAAV-mDlx-NLS-mRuby2An AAV genome that expresses nuclear localized mRuby2 from the mouse Dlx5/6 enhancer
99131pAAV-TRE-mNeonGreenAn AAV genome with tet-inducible expression of the fluorescent protein mNeonGreen
99132pAAV-TRE-DIO-mNeonGreenAn AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mNeonGreen
99133pAAV-CAG-fDIO-mNeonGreenAn AAV genome with Flp recombinase-dependent expression of mNeonGreen from the CAG promoter
99134pAAV-CAG-mNeonGreenAn AAV genome that ubiquitously expresses the fluorescent protein mNeonGreen from the CAG promoter
99135pAAV-hSyn1-mNeonGreenAn AAV genome that ubiquitously expresses the fluorescent protein mNeonGreen from the hSyn1 promoter
103005pUCmini-iCAP-PHP.eBnon-standard AAV2 rep-AAV-PHP.eB cap plasmid with AAV cap expression controlled by a tTA-TRE amplification system
103006pUCmini-iCAP-PHP.Snon-standard AAV2 rep-AAV-PHP.S cap plasmid with AAV cap expression controlled by a tTA-TRE amplification system

Antibodies from Article