Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M
Science. 2017 Aug 4;357(6350):503-507. doi: 10.1126/science.aan2475.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 89149 | pOTTC1328 - pAAV EF1a HA-hM3D(Gq) | An AAV packaging plasmid that expresses HA-tagged hM3D(Gq) excitatory DREADD from the EF1a promoter. |
| 89150 | pOTTC1329 - pAAV EF1a HA-hM4D(Gi) | An AAV packaging plasmid that expresses HA-tagged hM4D(Gi) inhibitory DREADD from the EF1a promoter. |