Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Showalter MR, Hatakeyama J, Cajka T, VanderVorst K, Carraway KL, Fiehn O
Elife. 2017 Jun 27;6. pii: e26030. doi: 10.7554/eLife.26030.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 87926 | pcDNA3.1-IDH2-WT | Expresses IDH2 (wild-type) in mammalian cells |
| 87927 | pcDNA3.1-IDH2-R172K | Expresses IDH2 (R172K mutant) in mammalian cells |