Studies on truncating mutations of SPAST associated with Hereditary Spastic Paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.
Solowska JM, Rao AN, Baas PW
Mol Biol Cell. 2017 May 11. pii: mbc.E17-01-0047. doi: 10.1091/mbc.E17-01-0047.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 92365 | pCMV-Tag/M1 N184X | expression of M1 N184X spastin in mammalian cells |
| 92366 | pCMV-Tag/M1 S245X | expression of M1 S245X spastin in mammalian cells |
| 92367 | pCMV-Tag/M87 N184X | expression of M87 N184X spastin in mammalian cells |
| 92368 | pCMV-Tag/M87 S245X | expression of M87 S245X spastin in mammalian cells |
| 92370 | pCMV-Tag/SP S245X with 5'UTR | expression of 245X spastin M1 and M87 in mammalian cells |
| 92371 | pTRE/SP M1 N184X | Inducible expression of M1 N184X spastin in mammalian cells |
| 92372 | pTRE/SP M1 S245X | Inducible expression of M1S245X spastin in mammalian cells |
| 92373 | pTRE/SP M87 N184X | Inducible expression of M87 N184X spastin in mammalian cells |
| 92374 | pTRE/SP M87 S245X | Inducible expression of M87 S245X spastin in mammalian cells |
| 92375 | pTRE/SP N184X with 5'UTR | Inducible expression of N184X spastin M1 and M87 in mammalian cells |
| 92376 | pTRE/SP S245X with 5'UTR | Inducible expression of S245X spastin M1 and M87 in mammalian cells |