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Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.

Mayerle M, Raghavan M, Ledoux S, Price A, Stepankiw N, Hadjivassiliou H, Moehle EA, Mendoza SD, Pleiss JA, Guthrie C, Abelson J
Proc Natl Acad Sci U S A. 2017 Apr 17. pii: 201701462. doi: 10.1073/pnas.1701462114. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
90964pRS313-PRP8yeast vector
90966pRS313 - prp8 V1860Nyeast vector
90967pRS313 - prp8 V1862Dyeast vector
90968pRS313 - prp8 T1865Kyeast vector
90969pRS313 - prp8 A1871Eyeast vector
90970pRS313 - prp8 T1872Eyeast vector
90971pRS313 - prp8 T1861Pyeast vector
90972pRS313 - prp8 V1862Yyeast vector
90973pRS313 - prp8 H1863Eyeast vector
90974pRS313 - prp8 K1864Eyeast vector
90975pRS313 - prp8 N1869Dyeast vector
90976pRS313 - prp8 V1870Nyeast vector
90977pRS313 - prp8 I1875Tyeast vector

Antibodies from Article