Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients.

Liu ML, Zang T, Zhang CL
Cell Rep. 2016 Jan 5;14(1):115-28. doi: 10.1016/j.celrep.2015.12.018. Epub 2015 Dec 24. (Link opens in a new window) PubMed (Link opens in a new window) Article

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ID	Plasmid	Purpose
90215	pCSC-ISL1-T2A-LHX3	To convert human skin fibroblasts into induced motor neurons (hiMN) in combination with NGN2, Sox11, FGF2 and two small molecules, forskolin and dorsomorphin.
90214	pCSC-NGN2-IRES-GFP-T2A-Sox11	To convert human skin fibroblasts into induced motor neurons (hiMN) in combination with ISL1, LHX3, FGF2 and two small molecules, forskolin and dorsomorphin.