Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD
Nature. 2016 Jul 7;535(7610):148-52. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
85457	SHP2(WT)@pLKO-Trex-SBP	Gene expression
85458	SHP2(T253M/Q257L)@pLKO-Trex-SBP	SHP2 mutant gene expression
85459	SHP2(C459S)@pLKO-Trex-HA	Expresses SHP2 mutant in mammalian cells