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Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
84824pBabe-HA-PHLPP1-delta-PHMammalian expression of a HA tagged, human PHLPP1 containing a deletion of the PH domain (delta PH) residues Q551 to R638 were deleted
84825pBabe-HA-PHLPP1-delta-PDZMammalian expression of a HA tagged, human PHLPP1 containing a deletion of the PDZ binding motif

Antibodies from Article