Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
Mertens J, Paquola AC, Ku M, Hatch E, Bohnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Goncalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH
Cell Stem Cell. 2015 Oct 6. pii: S1934-5909(15)00408-7. doi: 10.1016/j.stem.2015.09.001.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 71396 | pLVX-EF1alpha-2xGFP:NES-IRES-2xRFP:NLS | 2Gi2R assay |
| 84776 | pLVX-EF1a-tetOn-IRES-G418 (EtO) | Second generation lenti tetracycline operator (on) |
| 84777 | pLVX-TREtight-Ngn2:2A:Ascl1-PGK-Puro (XTP-N2A) | Second generation lenti expressing Mash1 and Neurogenin for iN transdifferentation to neurons |