A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing.
Liu KI, Ramli MN, Woo CW, Wang Y, Zhao T, Zhang X, Yim GR, Chong BY, Gowher A, Chua MZ, Jung J, Lee JH, Tan MH
Nat Chem Biol. 2016 Sep 12. doi: 10.1038/nchembio.2179.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 84232 | iCas | Expression of SpCas9 with 4 ERT2 fusion protein and empty gRNA cassette. The activity of Cas9 can be switched on and off in human cells with 4-hydroxytamoxifen (4-HT) |