A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.
Acevedo M, Vernier M, Mignacca L, Lessard F, Huot G, Moiseeva O, Bourdeau V, Ferbeyre G
Cancer Res. 2016 Jun 1;76(11):3252-64. doi: 10.1158/0008-5472.CAN-15-2347. Epub 2016 Mar 29.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 73549 | shNTC | Non-targeting control shRNA cloned in retroviral vector pMLP (MSCV-based vector expressing shRNA in a mir30 context). |
| 73550 | shCDK4(1) | shRNA(1) against CDK4 |
| 73551 | shCDK4(2) | shRNA(2) against CDK4 |
| 73552 | shCDK6(1) | shRNA(1) against CDK6 |
| 73553 | shCDK6(2) | shRNA(2) against CDK6 |
| 73554 | shCDK4/6(1) | vector encoding both shRNA against CDK4(1) and shRNA against CDK6(1) |
| 73555 | shCDK4/6(2) | vector encoding both shRNA against CDK4(2) and shRNA against CDK6(2) |
| 73556 | PML-ER-pBabe | vector encoding a fusion protein between PML-IV and ER (estrogen receptor) |
| 73557 | CDK2-3XFlag-pBabe | vector encoding a fusion protein between CDK2 and 3 Flag tags |
| 73558 | CDK4-3XFlag-pBabe | vector encoding a fusion protein between CDK4 and 3 Flag tags |
| 73559 | CDK4mut(K35M)-3XFlag-pBabe | vector encoding a fusion protein between a CDK4 mutant (K35M) and 3 Flag tags |
| 73560 | 3XFlag-pLPC | vector encoding 3 Flag tags |