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The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

Ismail IH, Gagne JP, Genois MM, Strickfaden H, McDonald D, Xu Z, Poirier GG, Masson JY, Hendzel MJ
Nat Cell Biol. 2015 Nov;17(11):1446-57. doi: 10.1038/ncb3259. Epub 2015 Oct 26. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
78920pEGFP-RNF138-WTMammalian expression of RNF138 with an EGFP fusion
78921pEGFP-RNF138-delta 18-58Mammalian expression of RNF138 with delta 18-58 and an EGFP fusion
78922pEGFP-RNF138-delta 86-105Mammalian expression of RNF138 with delta 86-105 and an EGFP fusion
78923pEGFP-RNF138-delta 158-180Mammalian expression of RNF138 with delta 158-180 and an EGFP fusion
78924pEGFP-RNF138-delta 189-215Mammalian expression of RNF138 with delta 189-215 and an EGFP fusion

Antibodies from Article